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TeresahRN
25252 posts
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MRSAid for Nasal Decolonization
MRSAid™ is a novel, non-antibiotic therapy for nasal bacterial decolonization to reduce the incidence of healthcare-acquired infections (HAI’s). MRSAid™ is based on the technology “Photodisinfection”, and consists of the application of a topical photosensitizer solution in the nasal passages of individuals colonized with potentially pathogenic bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). This solution is subsequently activated locally using non-thermal visible light energy. The treatment is painless, does not lead to bacterial resistance, and can decolonize the nose of Methicillin Resistant Staphylococcus aureus in a single several minute treatment.* As such, MRSAid™ is the first non-antibiotic solution for directly treating bacteria in the nose; which is the primary reservoir in humans for MRSA colonization.
* Nasal swabs and cultures, both before and after MRSAid™ treatment, have shown that carriers can be rendered plate negative for MRSA after a single several minute treatment.
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TeresahRN
25252 posts
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Photodisinfection
MRSAid™ treatment is based on the platform technology “Photodisinfection”. Photodisinfection involves the use of non-thermal light energy to activate a liquid photosensitizer formulation, leading to the generation of reactive oxygen-based molecules that are lethal to bacterial cells. These molecules are extremely short-lived, and destroy bacterial membranes via lipid peroxidation while causing little or no damage to surrounding tissue. Photodisinfection has been shown to be effective against a wide range of bacteria (including biofilm forms), as well as against various fungi and viruses. The same technology has been in widespread use in Canada since 2006 for the treatment of adult periodontal disease
Photodisinfection represents an ideal approach to bacterial decolonization therapy due to the following key attributes:
Treatment does not lead to the generation of bacterial resistance
The antimicrobial effect is powerful, immediate, and highly localized
The cytotoxic effect is primarily limited to bacterial cells (vs. eukaryotic cells), resulting in an attractive safety profile
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TeresahRN
25252 posts
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Reducing Surgical Site Infections With Photodisinfection
4 January 2013
The Canadian company Ondine Biomedical has announced the results of the first ever pilot programme of nasal decontamination to utilise photodisinfection, reporting a 39% reduction of surgical site infections (SSI). The technology was invented at UCL Eastman Dental Institute by Professor Michael Wilson for the prevention and treatment of infectious diseases.
Photodisinfection is a rapid, non-antibiotic, antimicrobial treatment that can be used minutes before surgery. By the application of a photosensitising dye and light, photodisinfection can significantly decrease the presence of targeted pathogens, being able to kill harmful bacteria such as MRSA. It has the potential to reduce the use of antibiotics – antibiotic resistance having been identified by the World Health Organisation as a threat to public health globally.
The study in question was carried out at Vancouver General Hospital (VGH) and involved using the technology, in conjunction with chlorhexidine body wipes, to eliminate bacteria inside the noses of patients immediately prior to major elective surgery.
Surgical site infections require on average more than eight days extension of hospital stays; major infections involving MRSA can result in hospital stays that exceed many months. Patients who develop infections after surgery are five times more likely to be readmitted to hospital, and twice as likely to die. As such, reduction in SSI is extremely important.
More than 5,000 patients were involved in the year-long pilot programme that saw a decrease in SSI from 4 to 1.25 cases per month. It resulted in the freeing of 533 patient beds and an additional 138 surgeries performed, generating $1.9 million of savings to the hospital. As a consequence of the trial, observing benefits in excellent safety results, patient compliance and ease of work flow integration, VGH has adopted photodisinfection into its standard preoperative procedures.
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TeresahRN
25252 posts
back to top
|
Reducing Surgical Site Infections With Photodisinfection
4 January 2013
The Canadian company Ondine Biomedical has announced the results of the first ever pilot programme of nasal decontamination to utilise photodisinfection, reporting a 39% reduction of surgical site infections (SSI). The technology was invented at UCL Eastman Dental Institute by Professor Michael Wilson for the prevention and treatment of infectious diseases.
Photodisinfection is a rapid, non-antibiotic, antimicrobial treatment that can be used minutes before surgery. By the application of a photosensitising dye and light, photodisinfection can significantly decrease the presence of targeted pathogens, being able to kill harmful bacteria such as MRSA. It has the potential to reduce the use of antibiotics – antibiotic resistance having been identified by the World Health Organisation as a threat to public health globally.
The study in question was carried out at Vancouver General Hospital (VGH) and involved using the technology, in conjunction with chlorhexidine body wipes, to eliminate bacteria inside the noses of patients immediately prior to major elective surgery.
Surgical site infections require on average more than eight days extension of hospital stays; major infections involving MRSA can result in hospital stays that exceed many months. Patients who develop infections after surgery are five times more likely to be readmitted to hospital, and twice as likely to die. As such, reduction in SSI is extremely important.
More than 5,000 patients were involved in the year-long pilot programme that saw a decrease in SSI from 4 to 1.25 cases per month. It resulted in the freeing of 533 patient beds and an additional 138 surgeries performed, generating $1.9 million of savings to the hospital. As a consequence of the trial, observing benefits in excellent safety results, patient compliance and ease of work flow integration, VGH has adopted photodisinfection into its standard preoperative procedures.
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