Everything Nurses >> Rx Corner >> Dilaudid histamine release??
Dilaudid histamine release??
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Posted about 4 years ago Does anyone know, or could lead me in the ight direction, to find out if Dilaudid could elicit a similar histamine release as Morphine can? Had a patient that just received a pain pump, where the surgeon told me that there was significant leakage of dilaudid. About a half hour after getting the patient from surgery, the patient developed flushing, hives and itching without symptoms of anaphylaxis. The surgeon blamed it on the contrast dye; but, I am wondering if it is possible to have the histamine release from the dilaudid? |
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| Posted about 4 years ago Bumping this up. Does anyone have an input or even ideas regarding this?????? |
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| Posted about 4 years ago No clue. Did you Google it? |
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| Posted about 4 years ago Yep, no help there. Even tried a literature review and couldn't find anything. Unable to find full product information that is supposed to explain the mechanism of action; but, am only pulling up the basics. Asked the pharmacist and two docs-I dunno, was essentially their answer(s). No problem finding information about histamine release with morphine, it is just the morphine derivatives that I am having trouble with. But, thanks for your response. |
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| Posted about 4 years ago It was my understanding that ANY drug can stimulate a histamine release. People can be 'mildly' allergic to any drug, not everyone has full blown anaphylaxis. I have had pt's with general itching and redness from ABX, and have been ordered to continue ABX and medicate with benadryl prior to each dose, to minimize histamine release. People can have small amount of histamine release in the same way, that people are in allergy season (eye redness, itchy eyes, etc). ...and have to take a anti-histamine medication ..... |
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| Posted about 4 years ago Lengthy article of hives and histamine and causes http://www.miramardermatology.com/hives.htm
"Hives are formed by blood plasma leaking out of small blood vessels in the skin. This is caused by the release of a chemical called histamine. Histamine is released from cells called "mast cells" that lie along the blood vessels in the skin. Allergic reactions, chemicals in foods, or medications can cause histamine release. Sometimes it's impossible to find out why hives are forming. Hives are very common – 10 to 20 percent of the population will have at least one episode in their lifetime. Most episodes of hives disappear quickly, in a few days to a few weeks. Occasionally, a person will continue to have hives for many years." Drugs Almost any prescription or over-the-counter medication can cause hives. Some of those drugs include antibiotics, pain medications, sedatives, tranquilizers, and diuretics (fluid pills). Diet supplements, antacids, arthritis medication, vitamins, eye drops and eardrops, laxatives, vaginal douches, or any other non-prescription item can be a potential cause of hives. If you have an attack of hives, it's important to tell your doctor about all of the preparations that you use to assist in finding the cause.
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| Posted almost 5 years ago I appreciate your help, Kittyrn-thanks! |
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| Posted almost 5 years ago I would like to add, that 15 + years ago, most all the pt's in the hospital were on IV tagamet, pepcid or zantac....these are all H2 blockers, and we saw a lot less of the mild histamine releases due to other drugs (narcs, ABX), but now everyone seems to be on stuff like protonix or prevacid (PPI's).......... I know that I see a heck of a lot more generalized itching than I ever saw when people used to be on the H2 blockers. |
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| Posted almost 5 years ago Great insight! You are absolutely right. Didn't put two and two together until you mentioned it. I think we both have the potential for some research studies here. |
